QSP Modeling Lead, Digital Medicine, Orion Corporation (Finland or USA)

Have experience in Quantitative Systems Pharmacology (QSP) for discovery and early drug development? Interested in data-driven research and development? If you have an entrepreneurial mindset and are eager for new challenges in QSP modeling, Orion's Digital Medicine department wants to hear from you!

Description of position

We're looking for an experienced Senior/Principal-level QSP expert with a data-driven discovery mindset, industry modeling experience, collaboration with early drug development colleagues, familiarity with biology aspects in oncology and pain, and knowledge of experimental methods.

You will collaborate with internal and external experts, teams, and projects, helping develop innovative methods for modeling efficacy and safety. As part of our computational biology team, you'll create your own methods and pipelines, contributing to our shift toward data-driven research and development. Extensive collaboration with internal/external functions, partners, and research biologists is expected.

Quantitative Systems Pharmacology (QSP) is a modeling and simulation approach used in pharmacology and drug development to understand and predict complex biological system responses to drug compounds. These models integrate biological, pharmacological, and physiological data to uncover how drugs interact with the body and affect disease processes, encompassing various factors like drug properties, molecular pathways, patient variability, and their impact on diseases.

QSP models support drug development at all stages, from preclinical research to clinical trials and beyond, aiding in dose optimization, biomarker identification, safety and efficacy assessment, and drug development decision-making.

This role is available in Espoo or Turku, Finland (with relocation support) or in NYC, US.

Description of unit

We are an agile, entrepreneurial, and global department driven by R&D. Our mission values the potential of data, science, and cutting-edge technologies, with the goal of aiding patients with life-threatening illnesses. Our pioneering project is at the forefront of a data and data science-driven ecosystem that has the potential to revolutionize pharmaceutical research (https://www.orion.fi/en/ecosystem). Through the utilization of advanced analytics and innovative methodologies, we aim to unearth new insights and streamline research processes, ultimately reshaping healthcare outcomes. Join us for a dynamic and flexible role that spans from initial discovery to the start of clinical trials.

We offer

We offer you highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting work in a modern multidisciplinary environment.

Generous health and welfare benefits are available, as well as corporate development and training opportunities.

Orion’s Sustainability Agenda sets the guidelines for the future and includes Patient safety as a top priority, Active work for a better environment, Care for well-being professionals, and Ethics at the core of our business.

To find further information about Orion as an employer please follow the link https://www.orion.fi/en/careers/orion-as-an-employer/ and read about Orion’s Scientist relocation journey to Finland here https://www.orion.fi/en/newsroom/all-news/articles/we-are-orion/finlands-good-reputation-attracted-bryce-nelson-to-work-in-finland/

Requirements

You are PhD from a suitable field (e.g., biology, pharmacology, mathematics, computational biology), and have industry relevant experience in QSP modeling. Experience of the QSP in cancer and/or pain will be a plus.

Also, extensive experience with exploratory data analysis, modeling and simulation with e.g. Python or R is required.

You will need to be able to work as part of various teams, and thus good communication and interpersonal skills are needed.

Additional information

If you are the person we are looking for, please submit your cover letter and CV by 31st January 2024.

For more information on the QSP Modeling Lead, please contact Sammeli Liikkanen, Director, Digital Medicine, tel. +358 509667466 (EET daytime).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Orion Corporation operates in more than 30 countries, where we Orionees, 3500 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.